Clinical concerns and considerations for leucovorin use in autism spe…
Published May 9, 2026
A clinical review of folinic acid (leucovorin) in autism that stresses mixed evidence, potential harms, and prescriber oversight.
<p><em>This clinical review discusses folinic acid (leucovorin) in relation to autism. It is an expert review, not a clinical trial or treatment guideline.</em></p><p><em>Evidence is mixed, and leucovorin is not an established treatment for autism. The American Academy of Pediatrics does not currently recommend leucovorin for autistic children. Potential benefits, harms, interactions, and any possible role in an individual’s care require careful medical assessment.</em></p><p><em>Do not start, stop, or change a medication or supplement based on this resource. Any discussion of leucovorin should take place with an appropriately qualified prescribing clinician.</em></p><p><em>Source: Howard C, Mekhail J, Ravikoff LM, Milanaik R. “Clinical Concerns and Considerations for Leucovorin Use in Autism Spectrum Disorder.” Current Opinion in Pediatrics. 2026;38(2):207–211. </em><a target="blank" rel="noopener noreferrer" href="https://doi.org/10.1097/MOP.0000000000001547"><em>https://doi.org/10.1097/MOP.0000000000001547</em></a><em> (PMID: 41670435).</em></p>